Molecular Mechanisms of DNA Damage Initiated by a,b-Unsaturated Carbonyl Compounds As Criteria for Genotoxicity and Mutagenicity
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of DNA damage initiated by alpha, beta-unsaturated carbonyl compounds as criteria for genotoxicity and mutagenicity.
alpha, beta-Unsaturated carbonyl compounds are important not only from a theoretical but also a practical standpoint. These ubiquitous compounds can interact with DNA through various mechanisms. The predominant interaction is the formation of cyclic 1,N2-deoxyguanosine adducts; 7,8-cyclic guanine adducts are also found. We have synthesized and characterized the stereoisomers of adducts formed b...
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ome of the most useful reactions of carbonyl compounds involve carbonhydrogen bonds adjacent to the carbonyl group. Such reactions, which can be regarded as the backbone of much synthetic organic chemistry, usually result in the replacement of the hydrogen by some other atom or group, as in the I I I I sequence H-C-C=O -+ X-C-C=O. The important examples we I I will consider in this chapter are ...
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*Correspondence: Takashi Yagi, Laboratory of Molecular and Cellular Genetics, Department of Biology, Graduate School of Science and Radiation Research Center, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan e-mail: [email protected] Formaldehyde is commonly used in the chemical industry and is present in the environment, such as vehicle emissions, ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1990
ISSN: 0091-6765
DOI: 10.2307/3431058